Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversionArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] addition antibodies Antibody Response approach AUC collected COVID-19 COVID-19 patient diagnostic diagnostics Donor Extreme early-stage seroconversion faster flow cytometry healthy IgG IgG and IgM IgG/IgM antibodies IgM immunoassay immunoassays immunological inactivated nucleic acid nucleic acids other diseases pathogen-specific Patient peptide platform probe Protein RBD reveal Rhesus monkeys SARS-CoV-2 S2 sensitivity Seroconversion seroconversion time Simoa tested Ultrasensitive digital detection. vaccination virus wild-type [DOI] 10.1016/j.bios.2022.114710 PMC 바로가기
Influenza and pneumococcal vaccination and COVID-19 in kidney transplant patientsResearch article Published on 2022-12-012022-10-05 Journal: Transplant immunology [Category] 변종, 진단, 치료제, [키워드] addition administration benefit Clinical course control group COVID COVID-19 COVID-19 infection disease Donor dysfunction examined follow-up time group Hospital stay Hospitalization increased the risk Influenza Influenza and pneumoccal vaccine intensive care kidney transplant kidney transplant recipient lack Logistic regression analysis median multivariate need for dialysis no significant difference observation outcome pandemic Patient pneumococcal positive recipient reduce Result risk of COVID-19 rRT-PCR test significantly higher the disease the patient vaccination vaccination rate Vaccine Vaccines with COVID-19 [DOI] 10.1016/j.trim.2022.101693 [Article Type] Research article
Association between SARS-CoV-2 infection and de novo HLA donor specific antibody production in lung transplant recipients: Single-center studyArticle Published on 2022-11-012022-11-15 Journal: Human immunology [Category] SARS, 진단, 치료기술, [키워드] antibody antibody production association COVID-19 COVID-19 pandemic de novo diagnosed with COVID-19 Diagnosis Donor donor specific antibodies HLA HLA antibodies HLA class I incidence include Infection LTR lung transplant lung transplant. MFI morbidity and mortality no significant difference outcome performed raised recipient recipients respiratory retrospective SARS-COV-2 infection the median viral infection [DOI] 10.1016/j.humimm.2022.07.007 PMC 바로가기
Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sourcesArticle Published on 2022-10-292022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 Antibody titer CCP collected convalescent plasma COVID-19 Donor dose effective geometric geometric mean titer Immune escape Immunocompromised implication Infection lesson monoclonal antibodies monoclonal antibody mRNA vaccine neutralization neutralize Neutralizing Neutralizing antibody titer omicron Outpatient pandemic plasma plasma activity provide recipients reduction representing SARS-CoV-2 variant sera subject therapeutic Therapies uninfected vaccinee variant variants of concern [DOI] 10.1038/s41467-022-33864-y PMC 바로가기
A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two dosesArticle Published on 2022-10-252022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Administering boost caused coronavirus COVID-19 CP: Immunology Donor dose elicit elicited extended interval humoral Humoral response humoral responses individual Infection long interval mRNA vaccine observé omicron regimen robust SARS-CoV-2 SARS-CoV-2 BNT162b2 second dose significantly spike glycoproteins third mRNA vaccine dose vaccinated individuals variant variants of concern variants of concern. VoC VOCs [DOI] 10.1016/j.celrep.2022.111554 PMC 바로가기
Omicron Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization by Immunoglobulin Preparations Manufactured From Plasma Collected in the United States and EuropeArticle Published on 2022-10-172022-11-15 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody collected coronavirus coronavirus 2 coronavirus disease COVID-19 Donor Europe European Immunoglobulin Infection intravenous Intravenous immunoglobulin less neutralization Neutralizing Neutralizing antibodies new virus omicron pandemic plasma preparation Primary Immunodeficiency Prophylaxis Prophylaxis. proportion raising respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody potency the United State union United State vaccination variant virus [DOI] 10.1093/infdis/jiac358 PMC 바로가기
Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concernArticle Published on 2022-10-152022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Anti-spike antibody antibody cross-reactivity antigens approach Beta clone clones cross-reactivity discriminatory power Diseases Donor exhibit Gamma IgG1 IgG1 antibodies IgG1 response individual donor Infection lack MONITOR observation plasma plasma IgG1 polyclonal profile Protein recognize response responses SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant Spike protein Support the SARS-CoV-2 trimer variant virus Virus neutralization VoC VOCs wild type Wuhan [DOI] 10.1038/s41467-022-33899-1 PMC 바로가기
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics studyArticle Published on 2022-10-142022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abuse Accelerator Antibody Response association Biomarker BNT162b2 characterized clinical trial coronavirus Course COVID-19 COVID-19 patients Critical CXCL10 cytokine dataset develop Disease progression Donor drug early IFN signaling Eiger BioPharmaceuticals enrolled Enrollment heterogeneity Host identify immune immune marker immune response immune signature immunological immunology independent individual Infection Infectious disease Inflammation machine-learning majority marker MCP-3 MCP1 Medicine memory Mild mRNA vaccination natural infection outcome Outpatient outpatients Patient Pfizer-BioNTech plasma plasma protein Post-infection predict Predictive Predictive modeling proteomics provided receiving RIG-I SARS-CoV-2 SARS-CoV-2-infected patients severe symptoms Stanford Stanford University subsequent systems immunology T cell T cell memory the antibody response trajectory transcriptomics Vaccine viral shedding Virological viruses viruses. with COVID-19 [DOI] 10.7554/eLife.77943 PMC 바로가기
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patientsArticle Published on 2022-10-052022-11-16 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted analysis Analysis Appendix approach assumption available data Calabria carrier caused changes in characterisation clinical Clinical outcome Clinical research clinical study collected Commonwealth confidence interval confounders COVID-19 dataset DAVID development Donor emergence Epidemiology European European Commission fatality Foreign foundation Frequency funding global health Google.org group heterogeneity Horizon hospital hospitalised hospitalised patient Imperial College London include infecting Infection Infectious disease International IRCCS ISARIC Italian Joshua less Logistic regression lower mortality Medical Research Council Medicine Melinda Gate Microbiology Ministry of Health network NIHR NIHR HPRU Odds ratio office omicron opportunity outcome Oxford Patient PHE protection Public Health England Rapid relative frequencies reported symptom Research respiratory response responsible Rockefeller Foundation SARS-CoV-2 variant School Semple sensitivity analysis Sriniva study population subset Support supported Symptoms union unit University of Liverpool University of Oxford variant variants viral genomic information viruses viruses. with COVID-19 [DOI] 10.7554/eLife.80556 PMC 바로가기
Blood Endothelial-Cell Extracellular Vesicles as Potential Biomarkers for the Selection of Plasma in COVID-19 Convalescent Plasma TherapyArticle Published on 2022-10-042022-11-15 Journal: Cells [Category] 바이오마커, [키워드] Activation age anti-SARS-CoV-2 antibody Biomarkers Blood blood endothelium cardiovascular disease caused CCP CCP therapy Characteristics characterized clinical symptom Concentration consequence convalescent plasma Convalescent plasma therapy coronavirus disease COVID-19 death Donor downregulation Endothelial cell Endothelial dysfunction Endothelium evidenced excessive inflammation expected extracellular vesicle Extracellular vesicles extracellular vesicles. hospital ICAM1 identify individual infected individual inflammatory storm massive secretion mechanism mild symptoms mitochondrial dysfunction multi-organ failure onset of symptom overexpression parameter Peripheral blood plasma Potential pro-inflammatory pro-inflammatory cytokine progression promoted reflected selected Selection severity subset Symptoms the disease therapy vaccination Vascular endothelium vascular inflammation vessel was increased [DOI] 10.3390/cells11193122 PMC 바로가기